Regulation of phospholipid transport

Across TCGA cell cohorts, RNA activity of the Regulation of phospholipid transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP33, VANGL2, and SEC13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP33 grouped by Regulation of phospholipid transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARHGAP33 →	+1.158	+1.224	.001	<.001	3	4
OESOPHAGUS	VANGL2 →	+1.757	+0.928	.001	.009	3	4
OVARY	SEC13 →	-0.730	-1.183	.003	.006	3	4
LUNG_NSCLC_LUSC	C17orf113 →	+0.711	+0.889	<.001	.009	3	4
LUNG_NSCLC_LUSC	ANKRD13A →	-2.326	-1.563	<.001	.001	3	4
BREAST	SASH3 →	+0.090	+0.921	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP33 by Regulation of phospholipid transport activity — LARGE_INTESTINE

Explore this box plot interactively →