Regulation of phospholipid transport

Across TCGA cell cohorts, RNA activity of the Regulation of phospholipid transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TENT5B, SLC25A11, and CPA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipid transport activity versus TENT5B in PANCREAS (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TENT5B →	-1.213	-0.722	.001	.007	3	4
SKIN	SLC25A11 →	+0.765	+0.277	.003	.003	3	3
PANCREAS	CPA4 →	-2.090	-0.735	.001	.006	2	4
OVARY	GPC1 →	-2.689	-1.511	.003	<.001	3	3
LUNG_SCLC	THRA →	+0.902	+0.233	.003	.001	3	3
LUNG_SCLC	COQ8A →	+1.217	+0.217	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001138 vs TENT5B — PANCREAS

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