Positive regulation of endocytic recycling

Across TCGA patient cohorts, RNA activity of the Positive regulation of endocytic recycling pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are U2SURP, LENG8_S351, and EPB41L3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endocytic recycling activity versus U2SURP in GBM (Pearson r = -0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	U2SURP →	-0.317	-0.081	<.001	<.001	3	6
OV	LENG8_S351 →	-0.999	-0.075	<.001	<.001	3	6
GBM	EPB41L3 →	+0.517	+0.072	.001	.001	3	6
GBM	CAPG_S129 →	+0.553	+0.046	<.001	.007	3	6
GBM	RBM17 →	-0.259	-0.093	<.001	<.001	3	6
BRCA	CHERP →	-0.250	-0.051	.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001137 vs U2SURP — GBM

Explore this scatter interactively →