Positive regulation of endocytic recycling

Across TCGA cell cohorts, RNA activity of the Positive regulation of endocytic recycling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EHD1, GPR176, and ACTN4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endocytic recycling activity versus EHD1 in BLOOD_Lymphoma (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	EHD1 →	+1.133	+0.869	.003	.002	2	8
PANCREAS	GPR176 →	+2.394	+1.166	.001	.004	3	6
OESOPHAGUS	ACTN4 →	+1.113	+1.431	.003	<.001	3	6
OESOPHAGUS	SYTL2 →	+2.398	+0.868	<.001	.009	3	6
BONE	RTL8C →	+1.170	+1.665	.001	.002	3	6
SOFT_TISSUE	AFAP1 →	+1.960	+1.044	.003	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001137 vs EHD1 — BLOOD_Lymphoma

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