Regulation of endocytic recycling

Across TCGA patient cohorts, RNA activity of the Regulation of endocytic recycling pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP12, ZC3H8_S59, and MAP1B_S1779, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endocytic recycling activity versus AKAP12 in OV (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AKAP12 →	+0.589	+0.049	<.001	<.001	3	6
GBM	ZC3H8_S59 →	-0.418	-0.050	.004	.001	3	6
GBM	MAP1B_S1779 →	+0.520	+0.057	.004	<.001	3	6
LSCC	MAP1B_S1298 →	+0.748	+0.037	.001	.004	3	5
LUAD	GPATCH4 →	-0.373	-0.036	<.001	<.001	3	5
HNSC	SGCD →	+0.679	+0.053	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001135 vs AKAP12 — OV

Explore this scatter interactively →