Regulation of endocytic recycling

Across TCGA cell cohorts, RNA activity of the Regulation of endocytic recycling pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNMA1, FAM214B, and UCP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endocytic recycling activity versus PNMA1 in PANCREAS (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PNMA1 →	+0.662	+0.171	.001	.006	3	5
SKIN	FAM214B →	+0.970	+0.220	.006	.007	2	5
BLOOD_Leukemia	UCP2 →	+0.796	+0.169	.003	.001	3	4
LUNG_NSCLC_LUSC	MTFR1L →	+1.105	+0.275	.001	.004	3	4
BREAST	ANXA5 →	+1.091	+0.262	<.001	.002	3	4
PANCREAS	ITPK1 →	+1.446	+0.203	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001135 vs PNMA1 — PANCREAS

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