Reactive nitrogen species metabolic process

Across TCGA patient cohorts, RNA activity of the Reactive nitrogen species metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRA2, RBMS3, and EFEMP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reactive nitrogen species metabolic process activity versus LILRA2 in LSCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LILRA2 →	+0.420	+0.149	<.001	<.001	3	6
BRCA	RBMS3 →	+0.557	+0.114	<.001	<.001	3	6
BRCA	EFEMP1 →	+1.082	+0.118	<.001	<.001	3	5
HNSC	AQP9 →	+0.950	+0.128	<.001	.002	3	5
LSCC	PMP22 →	+0.494	+0.131	.002	<.001	3	5
LSCC	CSF3R →	+0.906	+0.169	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001057 vs LILRA2 — LSCC

Explore this scatter interactively →