Reactive nitrogen species metabolic process

Across TCGA cell cohorts, RNA activity of the Reactive nitrogen species metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCAR1, TOM1L2, and SMTN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCAR1 grouped by Reactive nitrogen species metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	BCAR1 →	-1.299	-1.072	<.001	.001	3	5
STOMACH	TOM1L2 →	-1.351	-1.035	.002	<.001	3	4
LIVER	SMTN →	-1.225	-1.045	.005	.002	3	4
LIVER	CCDC9B →	-3.406	-1.258	<.001	.002	3	4
PANCREAS	TTC9 →	-2.023	-0.780	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	FBXL2 →	-1.192	-1.229	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCAR1 by Reactive nitrogen species metabolic process activity — LIVER

Explore this box plot interactively →