Reactive nitrogen species metabolic process

Across TCGA cell cohorts, RNA activity of the Reactive nitrogen species metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYB5R3, GRTP1, and PRPF19, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reactive nitrogen species metabolic process activity versus CYB5R3 in PANCREAS (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CYB5R3 →	+0.940	+0.337	<.001	<.001	3	5
BONE	GRTP1 →	+2.205	+0.330	<.001	.008	3	5
LIVER	PRPF19 →	-1.428	-0.234	<.001	.001	3	5
LIVER	C2orf68 →	-0.837	-0.274	.005	<.001	3	5
LIVER	ATP6AP2 →	+1.014	+0.253	.004	<.001	3	5
LIVER	COPZ2 →	+2.856	+0.280	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001057 vs CYB5R3 — PANCREAS

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