Positive regulation of integrin-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of integrin-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OLFML3, SSC5D, and SORBS3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of integrin-mediated signaling pathway activity versus OLFML3 in BRCA (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OLFML3 →	+0.827	+0.058	<.001	<.001	3	9
BRCA	SSC5D →	+0.681	+0.042	<.001	<.001	3	8
LUAD	SORBS3 →	+0.357	+0.099	<.001	<.001	3	8
BRCA	FKBP7 →	+0.519	+0.060	<.001	<.001	3	8
HNSC	CNPY4 →	+0.379	+0.093	.003	.004	3	8
UCEC	CPQ →	+0.470	+0.087	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001046 vs OLFML3 — BRCA

Explore this scatter interactively →