Positive regulation of integrin-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of integrin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMA4, CALD1, and CDH11, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of integrin-mediated signaling pathway activity versus LAMA4 in OV (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LAMA4 →	+1.118	+0.226	.001	.001	3	9
BRCA	CALD1 →	+0.992	+0.327	<.001	<.001	3	9
OV	CDH11 →	+1.617	+0.262	<.001	<.001	3	9
OV	FSTL1 →	+0.876	+0.189	.003	.002	3	9
OV	FBN1 →	+1.454	+0.253	.001	<.001	3	9
GBM	BNC2 →	+0.924	+0.211	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001046 vs LAMA4 — OV

Explore this scatter interactively →