Positive regulation of integrin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of integrin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF540, FAM104B, and TENT5C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF540 grouped by Positive regulation of integrin-mediated signaling pathway-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZNF540 →	+1.069	+1.778	.001	<.001	3	3
BONE	FAM104B →	+0.868	+1.533	<.001	<.001	3	3
BONE	TENT5C →	-0.640	-1.661	.006	<.001	3	3
LARGE_INTESTINE	SNAPC2 →	-1.164	-1.530	<.001	<.001	3	3
LARGE_INTESTINE	COQ3 →	-0.803	-0.932	.004	.006	3	3
LARGE_INTESTINE	PHLDA2 →	-0.915	-0.884	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF540 by Positive regulation of integrin-mediated signaling pathway activity — BONE

Explore this box plot interactively →