Regulation of integrin-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of integrin-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EFEMP2, CCDC102A_S12, and HIP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of integrin-mediated signaling pathway activity versus EFEMP2 in OV (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EFEMP2 →	+0.692	+0.066	<.001	<.001	3	9
GBM	CCDC102A_S12 →	+0.598	+0.059	<.001	.006	3	8
PDAC	HIP1 →	+0.313	+0.061	<.001	<.001	3	8
BRCA	LUM →	+0.882	+0.046	<.001	<.001	3	8
UCEC	SORBS1 →	+0.830	+0.067	<.001	.003	3	8
OV	SORBS3 →	+0.401	+0.054	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001044 vs EFEMP2 — OV

Explore this scatter interactively →