Regulation of integrin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of integrin-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIMS1, HUNK, and BST1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LIMS1 grouped by Regulation of integrin-mediated signaling pathway-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LIMS1 →	-0.313	-2.236	.004	<.001	3	6
OVARY	HUNK →	+0.264	+1.082	.003	.002	2	6
BLOOD_Myeloma	BST1 →	-0.450	-0.632	.003	.003	2	5
PANCREAS	PHACTR4 →	-0.267	-1.460	<.001	<.001	3	4
BREAST	FKBP9P1 →	+0.143	+0.897	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	NUP37 →	+0.173	+1.021	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LIMS1 by Regulation of integrin-mediated signaling pathway activity — URINARY_TRACT

Explore this box plot interactively →