Regulation of integrin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of integrin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLSCR3, GID4, and CD99, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of integrin-mediated signaling pathway activity versus PLSCR3 in SKIN (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PLSCR3 →	+1.394	+0.330	<.001	<.001	3	5
SKIN	GID4 →	+0.745	+0.298	.001	.005	3	5
BLOOD_Leukemia	CD99 →	+2.019	+0.340	.004	<.001	3	4
LUNG_SCLC	MST1R →	-2.051	-0.265	.003	.003	3	4
BLOOD_Leukemia	DHX32 →	-1.697	-0.218	.001	.006	2	5
BREAST	BIK →	-1.638	-0.244	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001044 vs PLSCR3 — SKIN

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