Positive regulation of double-strand break repair via nonhomologous end joining

Across TCGA cell cohorts, RNA activity of the Positive regulation of double-strand break repair via nonhomologous end joining pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM181, TRAK1, and WDR48, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM181 grouped by Positive regulation of double-strand break repair via nonhomologous end joining-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMEM181 →	-1.248	-1.458	.001	<.001	3	4
URINARY_TRACT	TRAK1 →	-1.799	-1.880	.005	<.001	3	4
STOMACH	WDR48 →	-0.580	-0.925	.008	.005	3	4
PANCREAS	FMR1 →	-0.570	-1.234	.006	<.001	3	4
PANCREAS	KCNN4 →	-2.425	-1.072	.009	.006	2	5
PANCREAS	GORASP1 →	-0.539	-1.303	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM181 by Positive regulation of double-strand break repair via nonhomologous end joining activity — LUNG_SCLC

Explore this box plot interactively →