Negative regulation of double-strand break repair via nonhomologous end joining

Across TCGA patient cohorts, RNA activity of the Negative regulation of double-strand break repair via nonhomologous end joining pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CIT, RPL12_S38, and RRP36_S73, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of double-strand break repair via nonhomologous end joining activity versus CIT in LUAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CIT →	+0.928	+0.067	<.001	<.001	3	7
LSCC	RPL12_S38 →	+0.788	+0.056	<.001	<.001	3	6
LSCC	RRP36_S73 →	+0.816	+0.072	<.001	<.001	3	6
UCEC	TBC1D17 →	-0.245	-0.060	<.001	.004	3	6
UCEC	UTP4 →	+0.334	+0.102	<.001	<.001	3	6
BRCA	CDC20_S41 →	+0.814	+0.047	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001033 vs CIT — LUAD

Explore this scatter interactively →