Regulation of double-strand break repair via nonhomologous end joining

Across TCGA patient cohorts, RNA activity of the Regulation of double-strand break repair via nonhomologous end joining pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEIL3, KIF14, and CENPO, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of double-strand break repair via nonhomologous end joining activity versus NEIL3 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NEIL3 →	+0.596	+0.492	<.001	<.001	3	7
BRCA	KIF14 →	+1.270	+0.844	<.001	<.001	3	7
LSCC	CENPO →	+0.730	+0.294	<.001	<.001	3	7
LSCC	PARPBP →	+0.955	+0.387	<.001	<.001	3	7
GBM	ASPM →	+1.084	+0.697	<.001	<.001	3	7
GBM	NEK2 →	+0.921	+0.717	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001032 vs NEIL3 — BRCA

Explore this scatter interactively →