Regulation of double-strand break repair via nonhomologous end joining

Across TCGA cell cohorts, RNA activity of the Regulation of double-strand break repair via nonhomologous end joining pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXA1, ALDOC, and C14orf93, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of double-strand break repair via nonhomologous end joining activity versus HOXA1 in SOFT_TISSUE (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	HOXA1 →	+1.587	+0.218	<.001	.001	3	5
STOMACH	ALDOC →	-2.028	-0.245	<.001	.009	3	5
OESOPHAGUS	C14orf93 →	+0.938	+0.236	<.001	.005	3	4
SKIN	PPCDC →	-0.459	-0.147	.002	.006	3	4
SKIN	STING1 →	+1.108	+0.183	.003	<.001	3	4
LIVER	ABCB6 →	-1.976	-0.404	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001032 vs HOXA1 — SOFT_TISSUE

Explore this scatter interactively →