Positive regulation of endothelial cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Positive regulation of endothelial cell chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LTBP2, VCL_S346, and VCL_S795, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endothelial cell chemotaxis activity versus LTBP2 in UCEC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LTBP2 →	+1.010	+0.103	<.001	<.001	3	10
UCEC	VCL_S346 →	+0.589	+0.088	<.001	<.001	3	9
UCEC	VCL_S795 →	+0.637	+0.097	<.001	<.001	3	9
OV	COMP →	+1.269	+0.075	<.001	<.001	3	9
CCRCC	SORBS3 →	+0.414	+0.087	<.001	<.001	3	9
CCRCC	TLN1_S1164 →	+0.690	+0.081	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001028 vs LTBP2 — UCEC

Explore this scatter interactively →