Positive regulation of endothelial cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Positive regulation of endothelial cell chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMSB4X, HSPB1, and YWHAG, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endothelial cell chemotaxis activity versus TMSB4X in LIVER (Pearson r = 0.91).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TMSB4X →	+3.325	+0.479	<.001	<.001	3	17
URINARY_TRACT	HSPB1 →	+4.758	+1.574	.001	.004	3	15
URINARY_TRACT	YWHAG →	+2.326	+1.403	.001	.003	3	12
LARGE_INTESTINE	EIF3B →	+0.875	+0.780	.003	.006	3	11
CNS	PFDN1 →	+1.445	+0.284	<.001	<.001	3	11
URINARY_TRACT	SRM →	+2.440	+1.271	.002	.009	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001028 vs TMSB4X — LIVER

Explore this scatter interactively →