Regulation of endothelial cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of endothelial cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGRT, PAIP2B, and CCDC148, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FCGRT grouped by Regulation of endothelial cell chemotaxis-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FCGRT →	+2.361	+0.981	.002	.003	3	5
SKIN	PAIP2B →	+0.289	+0.631	.001	.009	3	4
URINARY_TRACT	CCDC148 →	+1.080	+2.470	.003	<.001	3	4
URINARY_TRACT	FBXO36 →	+0.715	+1.603	<.001	.002	3	4
BONE	NPHP4 →	+0.949	+1.204	.004	.002	3	4
BONE	ATAD3B →	+0.967	+1.248	.009	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FCGRT by Regulation of endothelial cell chemotaxis activity — KIDNEY

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