Regulation of endothelial cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of endothelial cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPCAM, HSPB1, and MORN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endothelial cell chemotaxis activity versus EPCAM in LIVER (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EPCAM →	-5.143	-0.527	.001	<.001	3	6
BLOOD_Lymphoma	HSPB1 →	+2.279	+0.315	.005	.002	3	6
LIVER	MORN2 →	+1.644	+0.525	.001	<.001	3	5
LUNG_SCLC	TMSB4X →	+1.770	+0.384	<.001	<.001	3	5
OESOPHAGUS	FBXO27 →	-2.029	-0.262	<.001	.004	3	4
KIDNEY	C19orf47 →	-0.798	-0.451	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001026 vs EPCAM — LIVER

Explore this scatter interactively →