Regulation of response to drug

Across TCGA patient cohorts, RNA activity of the Regulation of response to drug pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BACH1, GLMP, and GAPDHP16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to drug activity versus BACH1 in PDAC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	BACH1 →	+0.685	+0.185	<.001	<.001	3	4
HNSC	GLMP →	-0.565	-0.067	.006	.008	3	3
LSCC	GAPDHP16 →	+0.435	+1.065	.003	<.001	3	3
UCEC	ZBTB1 →	+0.582	+1.217	.002	<.001	3	3
UCEC	NCOA2 →	+0.410	+0.794	.003	.001	3	3
UCEC	WDFY3 →	+0.525	+0.783	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001023 vs BACH1 — PDAC

Explore this scatter interactively →