Regulation of response to drug

Across TCGA cell cohorts, RNA activity of the Regulation of response to drug pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS39, JHY, and SLX4IP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VPS39 grouped by Regulation of response to drug-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	VPS39 →	-0.525	-1.103	.003	.002	3	4
BLOOD_Leukemia	JHY →	-0.635	-0.910	.006	.008	3	4
LIVER	SLX4IP →	+0.663	+1.387	<.001	<.001	3	4
LARGE_INTESTINE	KLF10 →	-0.758	-0.693	.003	.006	3	3
PANCREAS	USP18 →	-1.547	-1.216	<.001	<.001	3	3
PANCREAS	DDT →	+0.742	+1.309	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VPS39 by Regulation of response to drug activity — PANCREAS

Explore this box plot interactively →