Positive regulation of skeletal muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of skeletal muscle cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HP1BP3_S156, XRCC6_T455, and CARMIL1_S122, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of skeletal muscle cell differentiation activity versus HP1BP3_S156 in OV (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HP1BP3_S156 →	-0.504	-0.054	.008	.002	3	6
UCEC	XRCC6_T455 →	-0.531	-0.160	<.001	.003	3	6
LSCC	CARMIL1_S122 →	-0.694	-0.072	.006	.004	3	6
PDAC	CDK1 →	-0.424	-0.100	<.001	<.001	3	6
HNSC	CSE1L →	-0.179	-0.074	.005	.002	3	6
PDAC	ECT2 →	-0.725	-0.098	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001016 vs HP1BP3_S156 — OV

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