Positive regulation of skeletal muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of skeletal muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNOT7, COQ8A, and DPAGT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of skeletal muscle cell differentiation activity versus CNOT7 in OVARY (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CNOT7 →	-0.922	-0.575	.002	.005	3	4
LARGE_INTESTINE	COQ8A →	-1.107	-0.389	<.001	.001	3	3
BLOOD_Lymphoma	DPAGT1 →	-1.071	-0.502	<.001	<.001	3	3
BLOOD_Lymphoma	DDX6 →	-0.836	-0.547	.004	<.001	3	3
BLOOD_Lymphoma	STK35 →	-0.716	-0.496	.001	<.001	3	3
BLOOD_Lymphoma	UTP11 →	-0.716	-0.393	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001016 vs CNOT7 — OVARY

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