Regulation of forebrain neuron differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of forebrain neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PROX1-AS1, PROX1, and RAB3IP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of forebrain neuron differentiation activity versus PROX1-AS1 in GBM (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PROX1-AS1 →	+0.559	+0.518	<.001	<.001	3	5
UCEC	PROX1 →	+2.184	+0.589	<.001	.001	2	5
GBM	RAB3IP →	+0.932	+0.635	<.001	<.001	3	4
UCEC	CHRNA3 →	+1.437	+0.698	<.001	<.001	3	4
BRCA	STK35 →	+0.453	+0.210	.003	.003	3	4
LUAD	CD70 →	-0.432	-0.649	.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000977 vs PROX1-AS1 — GBM

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