Positive regulation of corticosteroid hormone secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of corticosteroid hormone secretion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAMSAP3, STAB1, and C1R, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of corticosteroid hormone secretion activity versus CAMSAP3 in GBM (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CAMSAP3 →	-0.415	-0.068	<.001	<.001	3	8
GBM	STAB1 →	+0.467	+0.086	.003	.003	3	8
OV	C1R →	+0.654	+0.069	<.001	<.001	3	7
CCRCC	C2 →	+0.455	+0.080	.006	.005	3	7
OV	CNN2 →	+0.634	+0.059	<.001	.002	3	7
LSCC	DAB2 →	+0.289	+0.046	.003	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000848 vs CAMSAP3 — GBM

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