Positive regulation of corticosteroid hormone secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of corticosteroid hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLT8D2, PSRC1, and POC1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of corticosteroid hormone secretion activity versus GLT8D2 in LSCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GLT8D2 →	+0.705	+0.583	<.001	.009	3	5
UCEC	PSRC1 →	-0.612	-0.513	.002	.005	3	5
UCEC	POC1A →	-0.882	-0.642	<.001	<.001	3	5
UCEC	GINS1 →	-0.836	-0.737	<.001	<.001	3	5
GBM	CXCL12 →	+0.794	+0.553	<.001	<.001	3	5
LSCC	ARHGDIB →	+0.615	+0.673	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000848 vs GLT8D2 — LSCC

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