Positive regulation of corticosteroid hormone secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of corticosteroid hormone secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF32, MS4A5, and P4HTM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF32 grouped by Positive regulation of corticosteroid hormone secretion-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RNF32 →	-0.155	-1.804	<.001	<.001	3	4
BLOOD_Leukemia	MS4A5 →	+0.244	+1.663	<.001	<.001	3	4
OVARY	P4HTM →	-0.240	-1.375	<.001	<.001	3	4
LIVER	IDO1 →	+0.181	+0.393	.002	.001	3	4
PANCREAS	SORCS1 →	-0.186	-1.513	.002	<.001	3	3
PANCREAS	CYP4Z2P →	-0.214	-1.494	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF32 by Positive regulation of corticosteroid hormone secretion activity — PANCREAS

Explore this box plot interactively →