Positive regulation of steroid hormone secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of steroid hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, SLC11A1, and CLEC5A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of steroid hormone secretion activity versus SPP1 in HNSC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SPP1 →	+1.797	+0.860	<.001	<.001	3	8
GBM	SLC11A1 →	+1.126	+0.464	<.001	<.001	3	7
LSCC	CLEC5A →	+0.828	+0.671	<.001	.001	3	7
LUAD	OSMR →	+0.409	+0.437	.004	.006	3	6
GBM	TREM1 →	+1.343	+0.472	<.001	<.001	3	6
GBM	ARHGAP22 →	+0.928	+0.632	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000833 vs SPP1 — HNSC

Explore this scatter interactively →