Positive regulation of steroid hormone secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of steroid hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2F2, MAGED4, and TTYH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTF2F2 grouped by Positive regulation of steroid hormone secretion-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GTF2F2 →	-0.886	-1.457	.003	.001	3	5
SOFT_TISSUE	MAGED4 →	+2.781	+1.214	.005	.002	3	4
BONE	TTYH1 →	+2.337	+1.303	.002	<.001	3	4
SOFT_TISSUE	TCAIM →	-0.700	-1.234	.001	<.001	3	3
SOFT_TISSUE	MAGED4B →	+3.183	+1.198	.008	.002	3	3
STOMACH	SH2B2 →	+1.089	+0.869	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTF2F2 by Positive regulation of steroid hormone secretion activity — BONE

Explore this box plot interactively →