Regulation of heart morphogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of heart morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SVIL, TGFB2, and VSNL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart morphogenesis activity versus SVIL in COAD (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SVIL →	+0.296	+0.038	.008	.004	3	5
BRCA	TGFB2 →	+0.522	+0.045	<.001	.001	3	5
UCEC	VSNL1 →	+1.280	+0.131	.005	.003	3	5
UCEC	HMCN1 →	+0.491	+0.130	.001	<.001	3	5
BRCA	PTPN14 →	+0.314	+0.054	<.001	<.001	3	5
CCRCC	FSTL1 →	+0.772	+0.042	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000826 vs SVIL — COAD

Explore this scatter interactively →