Regulation of heart morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of heart morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRWD3, SOX4, and TRAT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRWD3 grouped by Regulation of heart morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BRWD3 →	-0.216	-0.252	.006	.002	2	5
KIDNEY	SOX4 →	+0.187	+0.123	.001	.005	3	3
BLOOD_Leukemia	TRAT1 →	-0.237	-1.615	<.001	<.001	3	3
BLOOD_Leukemia	LETM2 →	+0.257	+1.209	.006	.002	3	3
BREAST	PTP4A2 →	-0.143	-0.687	.002	.006	3	3
BONE	PCDHA10 →	+0.210	+0.232	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRWD3 by Regulation of heart morphogenesis activity — CNS

Explore this box plot interactively →