Regulation of heart morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of heart morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DKK1, BMP4, and ROBO1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart morphogenesis activity versus DKK1 in OVARY (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DKK1 →	+3.139	+0.362	<.001	.006	2	10
LUNG_NSCLC_LUSC	BMP4 →	+3.734	+0.269	.001	.004	3	7
BLOOD_Leukemia	ROBO1 →	+3.191	+1.121	<.001	<.001	3	6
CNS	SMO →	+1.433	+0.310	<.001	.006	3	6
BLOOD_Leukemia	BCL2L1 →	+1.078	+0.908	<.001	<.001	3	6
PANCREAS	WNK2 →	-1.798	-0.349	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000826 vs DKK1 — OVARY

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