Regulation of nucleotide-excision repair

Across TCGA patient cohorts, RNA activity of the Regulation of nucleotide-excision repair pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBTF, SRA1, and ZMYM2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nucleotide-excision repair activity versus UBTF in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UBTF →	+0.336	+0.056	<.001	<.001	3	8
OV	SRA1 →	-0.392	-0.046	.009	.006	3	7
LSCC	ZMYM2 →	+0.483	+0.063	<.001	<.001	3	7
GBM	DHX9 →	+0.218	+0.053	<.001	<.001	3	7
BRCA	ING4 →	+0.557	+0.039	<.001	<.001	3	7
HNSC	ISG20 →	-0.618	-0.064	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000819 vs UBTF — GBM

Explore this scatter interactively →