Regulation of nucleotide-excision repair

Across TCGA patient cohorts, RNA activity of the Regulation of nucleotide-excision repair pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COLEC12, TROAP, and EHMT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nucleotide-excision repair activity versus COLEC12 in OV (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COLEC12 →	-1.051	-0.438	<.001	.004	3	6
UCEC	TROAP →	+1.048	+0.248	.001	.008	3	6
GBM	EHMT2 →	+0.435	+1.118	<.001	<.001	3	6
LSCC	POLE →	+0.764	+0.342	<.001	<.001	3	6
GBM	IRAG1 →	-0.773	-0.974	.001	.003	3	6
COAD	PLPP7 →	-0.223	-0.163	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000819 vs COLEC12 — OV

Explore this scatter interactively →