Regulation of nucleotide-excision repair

Across TCGA cell cohorts, RNA activity of the Regulation of nucleotide-excision repair pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARID1A, SFPQ, and RRAS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nucleotide-excision repair activity versus ARID1A in BREAST (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ARID1A →	+1.172	+0.907	<.001	.004	3	7
BLOOD_Leukemia	SFPQ →	+0.595	+0.263	<.001	<.001	3	7
BLOOD_Lymphoma	RRAS →	-0.894	-0.191	.006	<.001	3	6
BLOOD_Lymphoma	RCC2 →	+0.784	+0.220	<.001	<.001	2	7
LUNG_NSCLC_LUAD	CHD4 →	+0.659	+0.804	.001	.005	3	6
LUNG_NSCLC_LUAD	HMGN2 →	+0.656	+0.955	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000819 vs ARID1A — BREAST

Explore this scatter interactively →