Regulation of barbed-end actin filament capping

Across TCGA patient cohorts, RNA activity of the Regulation of barbed-end actin filament capping pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARMIL1, FMNL1, and CARMIL2_S1381, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of barbed-end actin filament capping activity versus CARMIL1 in GBM (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CARMIL1 →	+0.399	+0.096	<.001	<.001	3	8
CCRCC	FMNL1 →	-0.540	-0.092	<.001	<.001	3	7
LSCC	CARMIL2_S1381 →	-0.971	-0.074	<.001	<.001	3	7
CCRCC	WIPF1 →	-0.310	-0.093	<.001	<.001	3	7
CCRCC	RCSD1 →	-0.349	-0.086	<.001	<.001	3	6
OV	CARMIL1_S122 →	+0.876	+0.084	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000812 vs CARMIL1 — GBM

Explore this scatter interactively →