Regulation of barbed-end actin filament capping

Across TCGA cell cohorts, RNA activity of the Regulation of barbed-end actin filament capping pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DROSHA, RBM38, and NKX2-8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DROSHA grouped by Regulation of barbed-end actin filament capping-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DROSHA →	+0.650	+1.308	.008	.007	3	3
SKIN	RBM38 →	+0.918	+1.313	.001	<.001	3	3
SKIN	NKX2-8 →	+0.464	+0.970	.003	.004	3	3
SKIN	GRAMD4 →	+1.361	+1.381	.004	.001	3	3
UPPER_AERODIGESTIVE_TRACT	ZDHHC18 →	+0.878	+0.377	<.001	.006	3	3
LUNG_NSCLC_LUSC	SMIM3 →	-1.956	-0.388	.002	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DROSHA by Regulation of barbed-end actin filament capping activity — SKIN

Explore this box plot interactively →