Negative regulation of anoikis

Across TCGA cell cohorts, RNA activity of the Negative regulation of anoikis pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF846, PLLP, and C1orf54, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF846 grouped by Negative regulation of anoikis-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZNF846 →	+1.221	+1.139	<.001	.007	3	4
LARGE_INTESTINE	PLLP →	+1.983	+1.068	<.001	.003	3	4
BLOOD_Lymphoma	C1orf54 →	-2.312	-1.950	.002	<.001	3	3
BLOOD_Lymphoma	ZNF576 →	-0.899	-2.428	.003	.002	3	3
BLOOD_Lymphoma	RANBP10 →	-0.649	-1.798	.004	<.001	2	4
BLOOD_Lymphoma	TEX261 →	-0.936	-1.959	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF846 by Negative regulation of anoikis activity — KIDNEY

Explore this box plot interactively →