Negative regulation of anoikis

Across TCGA cell cohorts, RNA activity of the Negative regulation of anoikis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRPPRC, CTRL, and IMPA2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of anoikis activity versus LRPPRC in BREAST (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LRPPRC →	-0.622	-0.370	.006	.001	2	9
STOMACH	CTRL →	-0.615	-0.309	.006	.005	3	6
SOFT_TISSUE	IMPA2 →	-2.520	-0.331	<.001	.009	3	6
PANCREAS	DDX60 →	+1.956	+0.311	.004	.003	3	5
LIVER	DDX60L →	+1.628	+0.442	<.001	<.001	3	5
BLOOD_Leukemia	MAST4 →	+1.092	+0.575	.004	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000811 vs LRPPRC — BREAST

Explore this scatter interactively →