Regulation of epithelial cell proliferation involved in lung morphogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of epithelial cell proliferation involved in lung morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN2, THBS3, and CLPX, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epithelial cell proliferation involved in lung morphogenesis activity versus TLN2 in LSCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TLN2 →	+0.471	+0.092	<.001	<.001	3	8
OV	THBS3 →	+0.624	+0.079	<.001	.001	3	7
LUAD	CLPX →	-0.315	-0.076	<.001	<.001	3	7
PDAC	MRPL51 →	-0.361	-0.078	.005	.006	3	7
GBM	CNRIP1 →	+0.504	+0.089	<.001	<.001	3	7
COAD	MRPL3 →	-0.329	-0.052	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000794 vs TLN2 — LSCC

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