Regulation of epithelial cell proliferation involved in lung morphogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of epithelial cell proliferation involved in lung morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFIB, LCMT2, and ZNF397, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epithelial cell proliferation involved in lung morphogenesis activity versus NFIB in GBM (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NFIB →	+0.917	+0.329	<.001	<.001	3	5
CCRCC	LCMT2 →	+0.245	+0.506	<.001	<.001	3	4
GBM	ZNF397 →	+0.393	+0.297	<.001	<.001	3	4
COAD	E2F3P1 →	-0.254	-0.473	<.001	.001	3	4
GBM	ZNF407 →	+0.214	+0.275	<.001	<.001	3	4
GBM	MEX3A →	+1.382	+0.370	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000794 vs NFIB — GBM

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