Regulation of epithelial cell proliferation involved in lung morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of epithelial cell proliferation involved in lung morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFIB, MYBBP1A, and MIF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epithelial cell proliferation involved in lung morphogenesis activity versus NFIB in BREAST (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NFIB →	-1.809	-0.137	<.001	<.001	3	5
OESOPHAGUS	MYBBP1A →	-0.891	-0.179	.003	.003	3	4
URINARY_TRACT	MIF →	-1.453	-0.309	<.001	.005	3	3
KIDNEY	ELFN2 →	+2.340	+0.135	.001	<.001	3	3
OESOPHAGUS	C1QBP →	-1.470	-0.224	<.001	.001	3	3
OESOPHAGUS	ACY3 →	+1.017	+0.163	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000794 vs NFIB — BREAST

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