Positive regulation of autophagosome assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of autophagosome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPA, RCOR3, and SAR1A_T139, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of autophagosome assembly activity versus PTPA in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PTPA →	+0.349	+0.049	<.001	<.001	3	6
PDAC	RCOR3 →	+0.293	+0.060	<.001	<.001	3	5
BRCA	SAR1A_T139 →	-0.603	-0.057	.001	<.001	3	4
HNSC	SPRYD4 →	+0.400	+0.107	<.001	<.001	3	4
UCEC	CD99 →	+0.335	+0.056	.006	.001	3	4
BRCA	KIF22_T463 →	-0.894	-0.066	.008	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000786 vs PTPA — BRCA

Explore this scatter interactively →