Positive regulation of autophagosome assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of autophagosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPH, ESCO2, and FANCG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of autophagosome assembly activity versus CENPH in HNSC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CENPH →	-0.704	-0.366	.005	.006	3	4
UCEC	ESCO2 →	-0.613	-0.238	.002	.003	3	4
UCEC	FANCG →	-0.438	-0.197	<.001	<.001	3	4
BRCA	RPS26P20 →	-0.283	-0.103	.008	.004	3	4
LSCC	EPOP →	-0.898	-0.173	<.001	<.001	3	4
BRCA	RPL19 →	-0.610	-0.117	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000786 vs CENPH — HNSC

Explore this scatter interactively →