Regulation of autophagosome assembly

Across TCGA cell cohorts, RNA activity of the Regulation of autophagosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL24, ZER1, and HBP1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of autophagosome assembly activity versus KLHL24 in OESOPHAGUS (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KLHL24 →	+1.619	+0.080	.002	<.001	3	16
OESOPHAGUS	ZER1 →	+1.143	+0.076	<.001	<.001	3	16
URINARY_TRACT	HBP1 →	+1.333	+0.063	<.001	.001	3	15
OESOPHAGUS	TOM1 →	+1.177	+0.080	.002	.004	3	15
BLOOD_Lymphoma	CREBRF →	+0.983	+0.060	<.001	<.001	3	15
LUNG_SCLC	STAT2 →	+1.057	+0.052	<.001	.007	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000785 vs KLHL24 — OESOPHAGUS

Explore this scatter interactively →