Positive regulation of double-strand break repair

Across TCGA patient cohorts, RNA activity of the Positive regulation of double-strand break repair pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC1A, STAG2, and TMPO, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of double-strand break repair activity versus SMC1A in GBM (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC1A →	+0.411	+0.036	.001	.007	3	7
GBM	STAG2 →	+0.365	+0.043	.008	.001	3	7
GBM	TMPO →	+0.324	+0.034	<.001	<.001	3	7
LUAD	BRCA1_S114 →	+0.891	+0.024	.005	.007	3	7
LSCC	BRD8 →	+0.260	+0.039	<.001	<.001	3	7
GBM	ADNP →	+0.477	+0.046	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000781 vs SMC1A — GBM

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